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Coupling Reagents Daily Chemicals CAS 18162-48-6 Oxidizing Agent Decyanating Agent Silanizing Agent
Introduction:
White solid. Melting point 86-89℃, boiling point 128℃. Soluble in most organic solvents, usually used in CH2Cl2, THF and DMF. The reagent is sensitive to moisture and has a pungent taste. This product is corrosive and flammable. It is recommended to use it in anhydrous systems and operate and use it in a fume hood.
Uses:
Tert-butyldimethylchlorosilane (TBDMSCl) is a commonly used silanizing agent and one of the most widely used important protecting groups in organic synthesis. It is used as a protecting group for hydroxyl groups in the synthesis of ribonucleosides, and is also an oxidant and decyanant. It can react with hydroxyl groups under mild conditions to generate the corresponding silyl ethers, and react with ketones, esters or amides to generate the corresponding enol silyl ethers. Silanizing agent. In organic synthesis, it is used as a hydroxyl protecting agent and a derivatization reagent for analysis and preparation. Protect tertiary alcohols. React with alcohols to form silyl ethers. Determine the conformation of cholesterol derivatives. Synthesize prostaglandins, auxiliary raw materials for certain antibiotics, and lipid-lowering drugs such as lovastatin and simvastatin.
| Product Name | tert-Butyldimethylsilyl chloride |
| CAS | 18162-48-6 |
| MF | C6H15ClSi |
| MW | 150.72 |
| EINECS | 242-042-4 |
| Color | white crystalline powder |
